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The Born Immune Study – immunomonitoring in the neonatal intensive care unit

Research nurse Anna Karin Bernhardsson talks about how the Cytodelics Whole Blood Stabilizer enabled them to collect minute blood samples from newborn babies under stressful conditions.

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All published papers using our products


Bach FA, Muñoz Sandoval D, Mazurczyk M, Themistocleous Y, Rawlinson TA, Harding AC, Kemp A, Silk SE, Barrett JR, Edwards NJ, Ivens A, Rayner JC, Minassian AM, Napolitani G, Draper SJ, Spence PJ. A systematic analysis of the human immune response to Plasmodium vivax. J Clin Invest. 2023 Oct 16;133(20):e152463. doi: 10.1172/JCI152463. PMID: 37616070; PMCID: PMC10575735.

Bennett SJ, et al. Immune profiling in Puerto Rican injection drug users with and without HIV-1 infection. J Leukoc Biol. 2023 Apr 12:qiad045. doi: 10.1093/jleuko/qiad045. Epub ahead of print. PMID: 37042743.

Rodriguez L, et al. Achieving symptom relief in patients with myalgic encephalomyelitis by targeting the neuro-immune interface and optimizing disease tolerance. Oxf Open Immunol. 2023 Apr 17;4(1):iqad003. doi: 10.1093/oxfimm/iqad003. PMID: 37255930; PMCID: PMC10148714.

Weeratunga P, et al. Single cell spatial analysis reveals inflammatory foci of immature neutrophil and CD8 T cells in COVID-19 lungs. Nat Commun. 2023 Nov 8;14(1):7216. doi: 10.1038/s41467-023-42421-0. PMID: 37940670; PMCID: PMC10632491.


Serra V, et al. Comparison of Whole Blood Cryopreservation Methods for Extensive Flow Cytometry Immunophenotyping. Cells. 2022 May 2;11(9):1527. doi: 10.3390/cells11091527. PMID: 35563832; PMCID: PMC9103885. 

Olin A, et al. Longitudinal analyses of development of the immune system during the first five years of life in relation to lifestyle. Allergy. 2022 Jan 29. doi: 10.1111/all.15232. Epub ahead of print. PMID: 35094423. 

Nguyen NA, et al. A comprehensive assessment of four whole blood stabilizers for flow-cytometric analysis of leukocyte populations. Cytometry A. 2022 Oct 24. doi: 10.1002/cyto.a.24700. Epub ahead of print. PMID: 36279192. 

Lavis P, et al. Chemerin plasma levels are increased in COVID-19 patients and are an independent risk factor of mortality. Front Immunol. 2022 Aug 12;13:941663. doi: 10.3389/fimmu.2022.941663. PMID: 36032171; PMCID: PMC9412239. 

COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium. Electronic address:; COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium. A blood atlas of COVID-19 defines hallmarks of disease severity and specificity. Cell. 2022 Mar 3;185(5):916-938.e58. doi: 10.1016/j.cell.2022.01.012. Epub 2022 Jan 21. PMID: 35216673; PMCID: PMC8776501. 

Carpén N, et al. Transplantation of maternal intestinal flora to the newborn after elective cesarean section (SECFLOR): study protocol for a double blinded randomized controlled trial. BMC Pediatr. 2022 Sep 29;22(1):565. doi: 10.1186/s12887-022-03609-3. PMID: 36175995; PMCID: PMC9521560. 

Brauns E, et al. Functional reprogramming of monocytes in patients with acute and convalescent severe COVID-19. JCI Insight. 2022 Apr 5;7(9):e154183. doi: 10.1172/jci.insight.154183. PMID: 35380990; PMCID: PMC9090263. 

Albayrak N, et al. Distinct Expression Patterns of Interleukin-22 Receptor 1 on Blood Hematopoietic Cells in SARS-CoV-2 Infection. Front Immunol. 2022 Mar 29;13:769839. doi: 10.3389/fimmu.2022.769839. PMID: 35422799; PMCID: PMC9004465. 


Zenarruzabeitia O, et al. T Cell Activation, Highly Armed Cytotoxic Cells and a Shift in Monocytes CD300 Receptors Expression Is Characteristic of Patients With Severe COVID-19. Front Immunol. 2021 Mar 11;12:655934. doi: 10.3389/fimmu.2021.655934. PMID: 33777054; PMCID: PMC7991729. 

Veenith T, et al. CATALYST trial protocol: a multicentre, open-label, phase II, multiarm trial for an early and accelerated evaluation of the potential treatments for COVID-19 in hospitalised adults. BMJ Open. 2021 Nov 11;11(11):e050202. doi: 10.1136/bmjopen-2021-050202. PMID: 34764169; PMCID: PMC8587583.

Syrimi E, et al. The immune landscape of SARS-CoV-2-associated Multisystem Inflammatory Syndrome in Children (MIS-C) from acute disease to recovery. iScience. 2021 Nov 19;24(11):103215. doi: 10.1016/j.isci.2021.103215. Epub 2021 Oct 2. PMID: 34632327; PMCID: PMC8487319. 

Silva CS, et al. High Dimensional Immune Profiling Reveals Different Response Patterns in Active and Latent Tuberculosis Following Stimulation With Mycobacterial Glycolipids. Front Immunol. 2021 Nov 23;12:727300. doi: 10.3389/fimmu.2021.727300. PMID: 34887849; PMCID: PMC8650708. 

Ren X, et al. COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas. Cell. 2021 Feb 3:S0092-8674(21)00148-3. doi: 10.1016/j.cell.2021.01.053. Epub ahead of print. PMID: 33657410; PMCID: PMC7857060. 

Payne K, et al. Immediate Sample Fixation Increases Circulating Tumour Cell (CTC) Capture and Preserves Phenotype in Head and Neck Squamous Cell Carcinoma: Towards a Standardised Approach to Microfluidic CTC Biomarker Discovery. Cancers (Basel). 2021 Nov 3;13(21):5519. doi: 10.3390/cancers13215519. PMID: 34771681; PMCID: PMC8583049. 

Jašarević E, et al. The composition of human vaginal microbiota transferred at birth affects offspring health in a mouse model. Nat Commun. 2021 Nov 1;12(1):6289. doi: 10.1038/s41467-021-26634-9. PMID: 34725359; PMCID: PMC8560944.

Henrick BM, et al. Bifidobacteria-mediated immune system imprinting early in life. Cell. 2021 Jun 15:S0092-8674(21)00660-7. doi: 10.1016/j.cell.2021.05.030. Epub ahead of print. PMID: 34143954.

Goubet AG, et al. Prolonged SARS-CoV-2 RNA virus shedding and lymphopenia are hallmarks of COVID-19 in cancer patients with poor prognosis. Cell Death Differ. 2021 Dec;28(12):3297-3315. doi: 10.1038/s41418-021-00817-9. Epub 2021 Jul 6. PMID: 34230615; PMCID: PMC8259103. 


Silvin A, et al. Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19. Cell. 2020 Sep 17;182(6):1401-1418.e18. doi: 10.1016/j.cell.2020.08.002. Epub 2020 Aug 5. PMID: 32810439; PMCID: PMC7405878. 

Sakkestad ST, et al. Whole blood preservation methods alter chemokine receptor detection in mass cytometry experiments. J Immunol Methods. 2020 Jan;476:112673. doi: 10.1016/j.jim.2019.112673. Epub 2019 Oct 17. PMID: 31629741. 

Rodriguez L, et al. Systems-Level Immunomonitoring from Acute to Recovery Phase of Severe COVID-19. Cell Rep Med. 2020 Aug 25;1(5):100078. doi: 10.1016/j.xcrm.2020.100078. Epub 2020 Aug 5. PMID: 32838342; PMCID: PMC7405891. 

Consiglio CR, et al. The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19. Cell. 2020 Nov 12;183(4):968-981.e7. doi: 10.1016/j.cell.2020.09.016. Epub 2020 Sep 6. PMID: 32966765; PMCID: PMC7474869.

Carter MJ, et al. Peripheral immunophenotypes in children with multisystem inflammatory syndrome associated with SARS-CoV-2 infection. Nat Med. 2020 Nov;26(11):1701-1707. doi: 10.1038/s41591-020-1054-6. Epub 2020 Aug 18. PMID: 32812012. 


Lakshmikanth T, Brodin P. Systems-Level Immune Monitoring by Mass Cytometry. Methods Mol Biol. 2019;1913:33-48. doi: 10.1007/978-1-4939-8979-9_3. PMID: 30666597.

Mold JE, et al. Cell generation dynamics underlying naive T-cell homeostasis in adult humans. PLoS Biol. 2019 Oct 29;17(10):e3000383. doi: 10.1371/journal.pbio.3000383. PMID: 31661488; PMCID: PMC6818757.

Papoutsoglou G, et al. Challenges in the Multivariate Analysis of Mass Cytometry Data: The Effect of Randomization. Cytometry A. 2019 Nov;95(11):1178-1190. doi: 10.1002/cyto.a.23908. Epub 2019 Nov 6. PMID: 31692248; PMCID: PMC7027760.


Olin A, et al. Stereotypic Immune System Development in Newborn Children. Cell. 2018 Aug 23;174(5):1277-1292.e14. doi: 10.1016/j.cell.2018.06.045. PMID: 30142345; PMCID: PMC6108833.